This is the first report of P. sclerotigenum as a causal agent of yam post-harvest disease in Côte d’Ivoire. Penicillium sclerotigenum was first described by Kim et al. (2008) as a pathogen responsible for yam tuber rot in south Korea. Penicillium sclerotigenum isolates were identified in both cultivated yam lineages, D. alata and D. cayennensis subsp. rotundata. Côte d’Ivoire is the only country in West Africa where both lineages contribute equally to production (Kouakou et al., 2023) and further monitoring is required to quantify losses and varietal resistance.